Role of ATM and the MRN complex in the cell DNA damage response and cancer

Our interest is in the genes and proteins involved in cellular response to DNA damage, particularly following exposure of cells to agents, such as ionising radiation, which cause DNA double strand breaks. We are particularly interested in the consequences for tumour development when these genes are mutated or protein function is lost.

We are currently studying;

(i). The role of the ATM protein and also the Mre11/Rad50/Nbs1 protein complex, as well as their interactions, in the DNA damage response in human cells.

(ii). The range of phenotypic variation amongst ataxia telangiectasia patients (deficient in the ATM protein) and the relationship with the residual level of ATM kinase activity in their cells in culture.

(iii). The role of de novo ATM mutations in the development of sporadic lymphoid tumours in the general population

Publications

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